Losartan potassium is an oral drug under the angiotensin II receptor antagonist class. This medication is primarily used in the treatment of hypertension and works in conjunction with other anti-hypertensives.

The first oral drug in the class of angiotensin II receptor antagonist, Losartan potassium is primarily used to treat hypertension or high blood pressure. It is currently on the market under the brand name Cozaar from Merck and Co. This medication is also available in generic form.

Clinical Use:

This medication works by blocking aldosterone-secreting and vasoconstricting effects of angiotensin at several receptor sites, including adrenal glands and vascular smooth muscle. The drug also improves urinary flow as well as gains excretion of magnesium, chloride, phosphate and calcium. It is currently available in tablet form in dosages of 25mg, 50mg and 100mg.

A study has been conducted to examine the use of Losartan potassium to treat breast cancer tumors. Results showed that the drug is successful in blocking reverse neoplastic changes caused by angiotensin II receptor antagonist.

Patient Monitoring:

If you or your loved one is taking Losartan, you need to watch out for hypersensitivity reactions, monitor blood pressure to determine the drug efficacy, assess kidney and liver function tests as well as electrolyte levels and to be alert for progressive azotemia, renal failure and oliguria in patients who have severe heart failure.

Risk Considerations:

Women who are in their second trimester or third trimester pregnancy are advised against taking Losartan potassium. The drug may cause birth defect or death to the baby. Discontinuing the drug is the safest thing to do as soon as you learn that you are pregnant. However, this drug should not have been taken without consulting a doctor, especially by people with cases of obstructive biliary disorder, hepatic impairment and heart failure.

This drug should be used with caution by Black people, breastfeeding or pregnant patients and children not older than 18 years old. This drug can be taken with or without meal. Be aware that it may take a month or more to see the full benefits of this medication.

Adverse reactions associated with Losartan potassium are insomnia, fatigue, dizziness and headache.